Lonart is a fixed-dose combination antimalarial containing Artemether and Lumefantrine. It is indicated for the treatment of acute uncomplicated Plasmodium falciparum malaria and is one of the widely used artemisinin-based combination therapies (ACTs). It is not used for malaria prevention or severe malaria.
Rating: ★★★★☆ (4.8/5)
Strengths
- Fast relief of malaria symptoms, often within 24–48 hours.
- High cure rates when taken correctly with all six doses over three days.
- WHO-recommended ACT principle reduces parasite resistance.
- Suitable for adults and children (with weight-based dosing).
- Generally well tolerated with a good safety profile.
Limitations
- Must be taken with food (preferably fatty food or milk) to improve absorption.
- Completing the full course is essential even if symptoms improve.
- Not suitable for severe malaria requiring injectable treatment.
- Should be used cautiously with medicines that prolong the QT interval or interact with CYP3A4.
Common Side Effects
- Headache
- Dizziness
- Loss of appetite
- Nausea or vomiting
- Muscle or joint pain
- Weakness
These are usually mild and temporary.